Peanut allergy: Fat molecule treatment may prevent severe reaction in mice

Consuming a fats molecule produced by intestine micro organism seems to supply safety in opposition to anaphylaxis brought on by peanut allergy


21 August 2022

Peanuts could cause severe allergic reactions

JJ Gouin / Alamy

Consuming a fats molecule produced by intestine micro organism may prevent mice with severe peanut allergic reactions from experiencing a life-threatening immune reaction. The findings recommend the strategy might prevent this anaphylaxis reaction in individuals with meals allergic reactions and it might even prevent individuals growing allergic reactions in the primary place.

Anaphylaxis generally entails nausea, stomach ache and impaired respiration or hassle swallowing. Over the previous decade, researchers have discovered {that a} fats molecule referred to as butyrate, which is produced by intestine micro organism, can cut back these allergic reactions in mice. People with meals allergic reactions additionally appear to have much less butyrate-producing micro organism than non-allergic individuals do, suggesting that boosting butyrate might assist them.

However, butyrate can scent like canine faeces or rancid butter, making it disagreeable to swallow. What’s extra, when taken orally, it breaks down earlier than reaching the decrease intestine the place its useful results happen.

Now, Shijie Cao on the University of Chicago in Illinois and his colleagues have developed a approach to masks the foul scent of butyrate and ship the molecule to the decrease intestine, by packaging it inside spherical capsules referred to as micelles which are as much as 30 nanometres broad. We developed this drug supply platform, polymeric micelles, to ship butyrate to the intestine to deal with meals allergic reactions, says Cao, who offered the work at a gathering of the American Chemical Society in Chicago on 21 August.

The researchers handled 80 mice with an antibiotic to scale back their ranges of butyrate-producing intestine micro organism, then gave them severe peanut allergic reactions by giving them peanut protein together with an immune-stimulating toxin for 4 weeks. They then gave the micelles to half the mice twice a day for 2 weeks, with the opposite half receiving a saline resolution as a management, earlier than feeding all the animals 1 milligram of peanut protein.

While the management mice developed anaphylaxis from the peanut protein, as measured by a drop in their core physique temperature and elevated immune exercise, the mice that obtained the micelles didn’t. It was a really thrilling second once we noticed the outcomes, that the butyrate prevented anaphylaxis, says Cao.

By analysing the micro organism in the mouse faeces earlier than and after treatment, the staff then discovered that the butyrate-carrying micelles boosted the expansion of butyrate-producing micro organism, suggesting that the treatment might alter the intestine microbiome to supply extra of its personal butyrate.

Were aiming for creating a distinct segment for these wholesome micro organism to develop utilizing this treatment, in order that the micelles dont should be taken for a really very long time, says Cao.

The researchers additionally hope that the treatment can be utilized to prevent individuals growing many varieties of meals allergic reactions in the primary place. The strategy ought to work on any meals allergen, says Cao. We think about the micelles might come in a packet, and also you simply add it to a glass of water.

Short-chain fatty acids [like butyrate] might completely prevent meals allergy, says Charles Mackay at Monash University in Melbourne, Australia. This work may have a big impact if the therapies work in people. We have to do the trials and I’m very optimistic. Existing therapies are crude and unconvincing.

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